human transcription factor SOX-2 Adenovirus

Name 
Ad-h-Sox2
Cat No 
1786
Availability
Immediate
Categories
Adenovirus, iPS stem cell factors, Over-Expression

The Sox family of genes is associated with maintaining pluripotency similar to Oct-3/4, although it is associated with multipotent and unipotent stem cells in contrast with Oct-3/4, which is exclusively expressed in pluripotent stem cells. While Sox2 was the initial gene used for induction by Yamanaka, other genes in the Sox family have been found to work as well in the induction process. Sox1 yields iPS cells with a similar efficiency as Sox2, and genes Sox3, Sox15, and Sox18 also generate iPS cells, although with decreased efficiency.

Co-expression of Oct4, Sox2, KLF4 and c-Myc (Yamanaka set) in somatic cell will lead to iPSC reprogramming. Using adenovirus to deliver these transcription factors has 2 main advantages – it does not incorporate into the targeted host and therefore avoids the potential for insertional mutagenesis, and the expression is transient for a brief amount of time in order for effective reprogramming to take place.

This adenovirus expresses human Sox2, and it can be used in combination with other iPSC factor for the induction of iPSC reprogramming.

1786
Ad-h-Sox2

Ready-to-use human transcription factor SOX-2 Adenovirus. Sox-2 Sox2 iPs adenovirus 1786

$475.00
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Product Details

Promoter
CMV (ubiquitous)
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Titer
1x10^10 PFU/ml
Viral Backbone
Human Adenovirus Type5 (dE1/E3)
Volume (µL)
200

Gene Reference Data

Alternate Names
ANOP3; MCOPS3; sex determining region Y-box 2; SRY (sex determining region Y)-box 2; SRY-related HMG-box gene 2; transcription factor SOX2; transcription factor SOX-2
Description (eCommerce)
SRY (sex determining region Y)- box 2 (SOX2) is a transcription factor involved in embryonic development and is critical to embryonic stem cell pluripotency. Mutations in the SOX2 gene are associated with microphthalmia syndromic type 3 (MCOPS3) a condition characterized by microphthalmia or anophthalmia.
Description (Vector)
This intronless gene encodes a member of the SRY-related HMG-box (SOX) family of transcription factors involved in the regulation of embryonic development and in the determination of cell fate. The product of this gene is required for stem-cell maintenance in the central nervous system, and also regulates gene expression in the stomach. Mutations in this gene have been associated with optic nerve hypoplasia and with syndromic microphthalmia, a severe form of structural eye malformation. This gene lies within an intron of another gene called SOX2 overlapping transcript (SOX2OT).
Gene ID
6657
Gene Name (eCommerce)
SRY-box 2
Gene Name (Vector)
SRY-box 2
Gene Symbol
SOX2
HGNC ID
HGNC:11195
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
954
Protein Name (eCommerce)
Transcription factor SOX-2
RefSeq ID
NM_003106
RefSeq Synonyms
NM_003106, BC013923,
Research Areas
Brain Development,Cardiac Development,Cardiology,Cardiovascular,Cell Cycle,Gene Expression,Hippo Signaling,MAPK Signaling,Neurobiology,Neurodevelopment,Notch Signaling,RNA Binding,Signal Transduction,Transcription Factor/Regulator,Wnt Signaling
Research Areas (Faceted)
signal_transduction,neurobiology,developmental_biology,cardiovascular,cell_biology,cell_cycle,genetics,transcription_translation,signal_transduction,developmental_biology,signal_transduction,neurobiology,developmental_biology,signal_transduction,genetics,transcription_translation,signal_transduction,developmental_biology
Species
human
Target Sentence
SRY (sex determining region Y)- box 2 (SOX2) is a transcription factor involved in embryonic development and is critical to embryonic stem cell pluripotency. Mutations in the SOX2 gene are associated with microphthalmia syndromic type 3 (MCOPS3) a condition characterized by microphthalmia or anophthalmia.
UniGene ID
Hs.518438
UniProt ID (eCommerce)
P48431

Related Citations

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.