Cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) Adenovirus

Name 
Ad-p15/MTS2
Cat No 
1595
Availability
Immediate
Categories
Adenovirus, Over-Expression

A family of cell cycle regulatory proteins designated mitotic inhibitors play a major role in regulating progression through the cell cycle. These proteins bind to cyclin dependent kinases and inhibit the catalytic activity of the Cdk-cyclin complexes. Members of the mitotic inhibitor family include p21, p27, p57, p16, p15, p18 and p19. p19 ARF is an alternative splice product of the murine p16 gene and is known to induce cell cycle arrest. The human homolog p14 ARF induces cell cycle arrest in both G1 and G2/M in a p53-dependent fashion. Kip2 p57, a negative regulator of cell proliferation, inhibits several G1 cyclin/CDK complexes.

1595
Ad-p15/MTS2

Ready-to-use Cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) Adenovirus. Ad-p15/MTS2, “Cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)”, P15, MTS2, TP15, INK4B, CDKN2B, p15/MTS2 adenovirus 1595

$690.00
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Product Details

Promoter
CMV (ubiquitous)
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Titer
1x10^10 PFU/ml
Viral Backbone
Human Adenovirus Type5 (dE1/E3)
Volume (µL)
200

Gene Reference Data

Alternate Names
CDK4I; INK4B; MTS2; P15; p15INK4b; TP15
Description (Vector)
CDKN2B lies adjacent to the tumor suppressor gene CDKN2A in a region that is frequently mutated and deleted in a wide variety of tumors. CDKN2B encodes a cyclin-dependent kinase inhibitor, which forms a complex with CDK4 or CDK6, and prevents the activation of the CDK kinases, thus the encoded protein functions as a cell growth regulator that controls cell cycle G1 progression. The expression of this gene was found to be dramatically induced by TGF beta, which suggested its role in the TGF beta induced growth inhibition. Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported.
Gene ID
1030
Gene Name (Vector)
cyclin dependent kinase inhibitor 2B
Gene Symbol
CDKN2B
HGNC ID
HGNC:1788
ORF Size (aa)
417
ORF Size (bp)
417 bp
RefSeq ID
NM_078487
RefSeq Synonyms
NM_078487, NM_004936, BC014469,
Species
human
UniGene ID
Hs.72901

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.