human CDKN2B shRNA silencing Adenovirus
Category: Adenovirus > shRNA-Silencing
Cat. No: shADV-204883
Availability:
5-8 weeks
Name:
Ad-h-CDKN2B-shRNA
This is an Adenovirus expressing shRNA for silencing of Human CDKN2B.
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Product Info
- Knockdown
- shRNA screening service available, please inquire about this service or other options.
Viral Details
- Viral Backbone
- Human Adenovirus Type5 (dE1/E3)
- Promoter
- U6
- Reporter
- eGFP (default), optional CFP, YFP, RFP, mCherry
- Storage Buffer
- DMEM, 2% BSA, 2.5% Glycerol
Gene Details
- Species
- Human
- Gene Symbol
- CDKN2B
- Gene Name
- cyclin dependent kinase inhibitor 2B
- Gene ID
- 1030
- Gene Synonyms
- CDK4I; INK4B; MTS2; P15; p15INK4b; TP15
- ORF Size
- 417 bp
- RefSeq#
- NM_078487
- Gene Description
- CDKN2B lies adjacent to the tumor suppressor gene CDKN2A in a region that is frequently mutated and deleted in a wide variety of tumors. CDKN2B encodes a cyclin-dependent kinase inhibitor, which forms a complex with CDK4 or CDK6, and prevents the activation of the CDK kinases, thus the encoded protein functions as a cell growth regulator that controls cell cycle G1 progression. The expression of this gene was found to be dramatically induced by TGF beta, which suggested its role in the TGF beta induced growth inhibition. Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported.
- UniGene ID
- Hs.72901
- HGNC ID
- HGNC:1788
Related Products
Control Products
Product | Cat No. |
---|---|
Ad-GFP-U6-shRNA | 1122 |
Ad-U6-Luc-RNAi | 1123 |
Ad-U6-RNAi | 1640 |
Ad-U6-shRNA-CFP | 1780 |
Ad-U6-shRNA-mCherry | 1781 |
Ad-U6-shRNA-RFP | 1782 |
Ad-U6-shRNA-YFP | 1783 |
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