Signal transducer and activator of transcription 1, 91kDa Adenovirus
Stats (signal transducers and activators of transcription) are tyrosine phosphorylated transcription factors activated by JAK family kinases. Various ligands, including interferons and growth factors, induce activation of the JAK kinases, which induce Stat activation. Stat1 and Stat2 are induced by IFN-alpha and form a heterodimer that is part of the ISGF-3 transcription factor complex. Stat3-beta is activated by EGF and IL-6. Stat3-alpha is activated by EGF. Highest expression of Stat4 is observed in the testis and myeloid cells. IL-12 has been identified as an activator of Stat4. Stat5 can be activated by prolactin and by IL-3. Stat6 is involved in IL-4 activated signaling pathways. Stat-1 and Stat-3 bind the serum-inducible element (SIE) and GAS/ISRE elements are also known to be STAT-binding sites.
1532
Ad-STAT1
Ready-to-use Signal transducer and activator of transcription 1, 91kDa Adenovirus. Ad-STAT1, “Signal transducer and activator of transcription 1, 91kDa”, STAT1, ISGF-3, STAT91 adenovirus 1532
Gene Reference Data
Alternate Names
CANDF7; IMD31A; IMD31B; IMD31C; ISGF-3; signal transducer and activator of transcription 1, 91kD; signal transducer and activator of transcription 1, 91kDa; signal transducer and activator of transcription 1-alpha/beta; STAT91; transcription factor ISGF-3 components p91/p84
Description (eCommerce)
STAT1 (signal transducer and activator of transcription 1) is a member of the STAT protein family). In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. STAT1 can be activated by various ligands including interferon-alpha, interferon-gamma, EGF, PDGF and IL6. This protein mediates the expression of a variety of genes, which is thought to be important for cell viability in response to different cell stimuli and pathogens [taken from NCBI Entrez Gene (GeneID: 6772)].
Description (Vector)
STAT1 is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein can be activated by various ligands including interferon-alpha, interferon-gamma, EGF, PDGF and IL6. This protein mediates the expression of a variety of genes, which is thought to be important for cell viability in response to different cell stimuli and pathogens. Two alternatively spliced transcript variants encoding distinct isoforms have been described.
Gene ID
6772
Gene Name (eCommerce)
signal transducer and activator of transcription 1
Gene Name (Vector)
signal transducer and activator of transcription 1
Gene Symbol
STAT1
HGNC ID
HGNC:11362
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2139
ORF Size (bp)
2139 bp
Protein Name (eCommerce)
Signal transducer and activator of transcription 1-alpha/beta
RefSeq ID
NM_007315
RefSeq Synonyms
NM_139266, NM_007315, BC002704,
Research Areas
Angiogenesis,Apoptosis,B-cell Receptor Signaling,BDNF Signaling,Breast Cancer,Cancer,Cardiovascular,Cytokine Signaling,EGFR Signaling,EPO Signaling,FGF Signaling,Host-Virus Interactions,IFN Signaling,Immunology,Interleukin Signaling,JAK-STAT Signaling,Leptin Signaling,MAPK Signaling,Neurobiology,NF-kB Signaling,PDGF Signaling,Prolactin Signaling,Prostate Cancer,RANKL-RANK Signaling,Response to Virus,SCF-KIT Signaling,Signal Transduction,T-cell Receptor Signaling,TGF-beta Signaling,TNF Signaling,Toll-like Receptor Signaling,TPO Signaling,Transcription Factor/Regulator,TSH Signaling,TSLP Signaling
Research Areas (Faceted)
cancer,cardiovascular,cell_biology,developmental_biology,immunology,infectious_disease,neurobiology,signal_transduction,stem_cell_biology,transcription_translation
Species
human
Target Sentence
STAT1 (signal transducer and activator of transcription 1) is a member of the STAT protein family). In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. STAT1 can be activated by various ligands including interferon-alpha, interferon-gamma, EGF, PDGF and IL6. This protein mediates the expression of a variety of genes, which is thought to be important for cell viability in response to different cell stimuli and pathogens [taken from NCBI Entrez Gene (GeneID: 6772)].
UniGene ID
Hs.715518
UniProt ID (eCommerce)
P42224
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.