Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha Adenovirus

Name 
Ad-iKBa
Cat No 
1504
Availability
Immediate
Categories
Adenovirus, Over-Expression

Members of the IkB family can be divided into four groups including IkB-alpha (including proteins previously referred to as pp40 and MAD-3), IkB-beta, IkB-gamma (a 70 kDa protein identical in sequence to the C-terminal domain of the p105 precursor of NFkB p50) and IkB-epsilon. Members of the IkB family exhibit differential inhibition of the DNA binding activity of various NFkB homodimeric and heterodimeric complexes. A functionally related protein, Bcl-3, is overexpressed in chronic lymphocytic leukemia.

1504
Ad-iKBa

Ready-to-use Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha Adenovirus. Ad-iKBa, “Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha”, IKBA, MAD-3, NFKBI, NFKBIA adenovirus 1504

$690.00
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Product Details

Promoter
CMV (ubiquitous)
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Titer
1x10^10 PFU/ml
Viral Backbone
Human Adenovirus Type5 (dE1/E3)
Volume (µL)
200

Gene Reference Data

Alternate Names
IKBA; MAD-3; NFKBI
Description (Vector)
NFKBIA encodes a member of the NF-kappa-B inhibitor family, which contain multiple ankrin repeat domains. The encoded protein interacts with REL dimers to inhibit NF-kappa-B/REL complexes which are involved in inflammatory responses. The encoded protein moves between the cytoplasm and the nucleus via a nuclear localization signal and CRM1-mediated nuclear export. Mutations in this gene have been found in ectodermal dysplasia anhidrotic with T-cell immunodeficiency autosomal dominant disease.
Gene ID
4792
Gene Name (Vector)
NFKB inhibitor alpha
Gene Symbol
NFKBIA
HGNC ID
HGNC:7797
ORF Size (aa)
954
ORF Size (bp)
954 bp
RefSeq ID
NM_020529
RefSeq Synonyms
NM_020529, BC004983, BC002601,
Species
human
UniGene ID
Hs.81328

Related Citations

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.