Sirtuin (silent mating type information regulation 2 homolog) 3 (S. cerevisiae) Adenovirus
Cat. No: 1499
The Silent Information Regulator (SIR2) family of genes are highly conserved from prokaryotes to eukaryotes and are involved in diverse processes, including transcriptional regulation, cell cycle progression, DNA-damage repair and aging. The human sirtuins, which include SIRT1-7, are divided into four main branches: SIRT1-3 are class I, SIRT4 is class II, SIRT5 is class III and SIRT6-7 are class IV. SIRT1 is widely expressed and regulates p53 function through its deacetylation at lysine 382.
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- Viral Backbone
- Human Adenovirus Type5 (dE1/E3)
- CMV (ubiquitous)
- Storage Buffer
- DMEM, 2% BSA, 2.5% Glycerol
- 1x10^10 PFU/ml
- Gene Symbol
- Gene ID
- Gene Synonyms
This product is referenced in the following publications:
- Sundaresan, N., etc. (2008). Sirt3 Is A Stress-Responsive Deacetylase In Cardiomyocytes That Protects Cells From Stress-Mediated Cell Death By Deacetylation Of Ku70. Molecular and Cellular Biology.
- SA Samant, etc (2013). SIRT3 deacetylates and activates OPA1 to regulate mitochondrial dynamics during stress. MCB.
- NR Sundaresan, (2015). SIRT3 blocks aging-associated tissue fibrosis in mice by deacetylating and activating GSK3ß. Molecular and Cellular Biology.
- H Zeng, etc (2016). LPS causes pericyte loss and microvascular dysfunction via disruption of Sirt3/angiopoietins/Tie-2 and HIF-2a/Notch3 pathways. Scientific Reports.
- Eun-Hee Cho (2016). SIRT3 regulates a-SMA production through the succinate dehydrogenase-GPR91 pathway in hepatic stellate cells. JBC.
- Bindu S, etc (2016). SIRT3 blocks myofibroblast differentiation and pulmonary fibrosis by preventing mitochondrial DNA damage. American Journal of Physiology - Lung Cellular and Molecular Physiology.