caveolin 1, caveolae protein, 22kDa Adenovirus
The scaffolding protein encoded by this gene is the main component of the caveolae plasma membranes found in most cell types. The protein links integrin subunits to the tyrosine kinase FYN, an initiating step in coupling integrins to the Ras-ERK pathway and promoting cell cycle progression. The gene is a tumor suppressor gene candidate and a negative regulator of the Ras-p42/44 MAP kinase cascade. CAV1 and CAV2 are located next to each other on chromosome 7 and express colocalizing proteins that form a stable hetero-oligomeric complex. By using alternative initiation codons in the same reading frame, two isoforms (alpha and beta) are encoded by a single transcript from this gene.
1364
Ad-Caveolin-1
Ready-to-use caveolin 1, caveolae protein, 22kDa Adenovirus. Ad-Caveolin-1, “caveolin 1, caveolae protein, 22kDa”, CAV, CAV1 adenovirus 1364
Gene Reference Data
Alternate Names
BSCL3; caveolin 1, caveolae protein, 22kDa; caveolin-1; cell growth-inhibiting protein 32; CGL3; LCCNS; MSTP085; PPH3; VIP21
Description (eCommerce)
CAV1 acts as a scaffolding protein within caveolar membranes and forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. CAV1 also mediates the recruitment of CAVIN proteins to the caveolae and interacts directly with G-protein alpha subunits and can functionally regulate their activity. CAV1 is also thought to be involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation, as its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner  [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q03135].
Description (Vector)
The scaffolding protein encoded by this gene is the main component of the caveolae plasma membranes found in most cell types. The protein links integrin subunits to the tyrosine kinase FYN, an initiating step in coupling integrins to the Ras-ERK pathway and promoting cell cycle progression. The gene is a tumor suppressor gene candidate and a negative regulator of the Ras-p42/44 mitogen-activated kinase cascade. Caveolin 1 and caveolin 2 are located next to each other on chromosome 7 and express colocalizing proteins that form a stable hetero-oligomeric complex. Mutations in this gene have been associated with Berardinelli-Seip congenital lipodystrophy. Alternatively spliced transcripts encode alpha and beta isoforms of caveolin 1.
Gene ID
857
Gene Name (eCommerce)
caveolin 1
Gene Name (Vector)
caveolin 1
Gene Symbol
CAV1
HGNC ID
HGNC:1527
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
537
Protein Name (eCommerce)
Caveolin-1
RefSeq ID
NM_001753
RefSeq Synonyms
NM_001753, NM_001172897, NM_001172896, NM_001172895, BC082246, BC009685,
Research Areas
Angiogenesis,Apoptosis,Cancer,Cardiology,Cardiovascular,EGFR Signaling,Estrogen Signaling,Golgi Apparatus,Host-Virus Interactions,Hypoxia,Immunology,Insulin Signaling,JAK-STAT Signaling,MAPK Signaling,Metabolism/Metabolic Process,Mitochondrion,PDGF Signaling,Signal Transduction,TGF-beta Signaling,TNF Signaling,VEGF Signaling,Wnt Signaling
Research Areas (Faceted)
cancer,signal_transduction,developmental_biology,cell_biology,cardiovascular,signal_transduction,cell_biology,infectious_disease,cell_biology,metabolism,immunology,signal_transduction,metabolism,signal_transduction,cell_biology,signal_transduction,immunology,developmental_biology
Species
human
Target Sentence
CAV1 acts as a scaffolding protein within caveolar membranes and forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. CAV1 also mediates the recruitment of CAVIN proteins to the caveolae and interacts directly with G-protein alpha subunits and can functionally regulate their activity. CAV1 is also thought to be involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation, as its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner  [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q03135].
UniGene ID
Hs.74034
UniProt ID (eCommerce)
Q03135
Related Citations
- Intermittent hypoxia regulates vasoactive molecules and alters insulin-signaling in vascular endothelial cells. P Sharma, etc, (2018), P Sharma, etc
- Curcumin enhances vascular contractility via induction of myocardin in mouse smooth muscle cells. Sun S, etc, (2017), Acta Pharmacologica Sinica
- Oral Absorption Enhancement of Probucol by PEGylated G5 PAMAM Dendrimer Modified Nanoliposomes. Q Ma, etc, (2015), Molecular pharmaceutics
- The role of caveolin-1 and syndecan-4 in the internalization of PEGylated PAMAM dendrimer polyplexes into myoblast and hepatic cells. Wenwen Shen, etc, (2014), European Journal of Pharmaceutics and Biopharmaceutics
- Caveolin-1 reduces HIV-1 infectivity by restoration of HIV Nef mediated impairment of cholesterol efflux by apoA-I. Lin, SS. etc, (2012), Retrovirology
- Caveolin 1 inhibits HIV replication by transcriptional repression mediated through NF-¿B. Wang XM, etc, (2011), J Virol
- Caveolin-1 is a negative regulator of MMP-1 gene expression in human dermal fibroblasts via inhibition of Erk1/2/Ets1 signaling pathway. Paul Haines, etc, (2011), Journal of Dermatological Science
- Caveolin-1 Induces Formation of Membrane Tubules That Sense Actomyosin Tension and Are Inhibited by Polymerase I and Transcript Release Factor/Cavin-1. Prakhar Verma, (2010), MBoC
- The Mechanism of Polyplexes Internalization into Cells: Testing the GM1/Caveolin-1-Mediated Lipid Raft Mediated Endocytosis Pathway. Rong Qi, etc, (2010), Mol Pharm
- The Mechanism Of Polyplex Internalization Into Cells: Testing The Gm1/Caveolin-1 Lipid Raft Mediated Endocytosis Pathway. Qi, R. etc, (2010), Mol. Pharmaceutics,
- Deciphering Mechanisms Controlling Placental Artery Endothelial Cell Migration Stimulated by Vascular Endothelial Growth Factor. Wu-xiang Liao, etc, (2010), Endocrinology
- Leptin upregulates caveolin-1 expression: Implications for development of atherosclerosis. P Singh,etc, (2010), Atherosclerosis
- Guanosine Triphosphate Cyclohydrolase I Expression And Enzymatic Activity Are Present In Caveolae Of Endothelial Cells. Peterson TE, etc, (2009), Hypertension
- Compartmentalizing Vegf-Induced Erk2/1 Signaling In Placental Artery Endothelial Cell Caveolae: A Paradoxical Role Of Caveolin-1 In Placental Angiogenesis In Vitro. Liao WX, etc., (2009), Molecular Endocrinology
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.