human CAV1 shRNA silencing AAV

BSCL3; caveolin 1, caveolae protein, 22kDa; caveolin-1; cell growth-inhibiting protein 32; CGL3; LCCNS; MSTP085; PPH3; VIP21

CAV1 acts as a scaffolding protein within caveolar membranes and forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. CAV1 also mediates the recruitment of CAVIN proteins to the caveolae and interacts directly with G-protein alpha subunits and can functionally regulate their activity. CAV1 is also thought to be involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation, as its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner  [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q03135].

The scaffolding protein encoded by this gene is the main component of the caveolae plasma membranes found in most cell types. The protein links integrin subunits to the tyrosine kinase FYN, an initiating step in coupling integrins to the Ras-ERK pathway and promoting cell cycle progression. The gene is a tumor suppressor gene candidate and a negative regulator of the Ras-p42/44 mitogen-activated kinase cascade. Caveolin 1 and caveolin 2 are located next to each other on chromosome 7 and express colocalizing proteins that form a stable hetero-oligomeric complex. Mutations in this gene have been associated with Berardinelli-Seip congenital lipodystrophy. Alternatively spliced transcripts encode alpha and beta isoforms of caveolin 1.

857

caveolin 1

caveolin 1

CAV1

HGNC:1527

9606.0

537

Caveolin-1

NM_001753

NM_001753, NM_001172897, NM_001172896, NM_001172895, BC082246, BC009685,

Angiogenesis,Apoptosis,Cancer,Cardiology,Cardiovascular,EGFR Signaling,Estrogen Signaling,Golgi Apparatus,Host-Virus Interactions,Hypoxia,Immunology,Insulin Signaling,JAK-STAT Signaling,MAPK Signaling,Metabolism/Metabolic Process,Mitochondrion,PDGF Signaling,Signal Transduction,TGF-beta Signaling,TNF Signaling,VEGF Signaling,Wnt Signaling

cancer,signal_transduction,developmental_biology,cell_biology,cardiovascular,signal_transduction,cell_biology,infectious_disease,cell_biology,metabolism,immunology,signal_transduction,metabolism,signal_transduction,cell_biology,signal_transduction,immunology,developmental_biology

human

CAV1 acts as a scaffolding protein within caveolar membranes and forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. CAV1 also mediates the recruitment of CAVIN proteins to the caveolae and interacts directly with G-protein alpha subunits and can functionally regulate their activity. CAV1 is also thought to be involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation, as its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner  [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q03135].

Hs.74034

Q03135