iKBa (S32A/S36A) Adenovirus
This recombinant adenovirus contains the dominant-negative mutant of I kappa B alpha (IkBa-S32A/S36A), which has serine-to-alanine substitutions at amino acids 32 and 36, respectively, and is resistant to phosphorylation-induced degradation of I kappa B alpha.
References: Kumar, A., Eby, M. T., Sinha, S., Jasmin, A., and Chaudhary, P. M. (2000) J. Biol. Chem. 276, 2668-2677
1028
Ad-CMV-iKB(DN)
Ready-to-use iKBa (S32A/S36A) Adenovirus. iKB p65 NFkB c-rel I kappa B adenovirus 1028
Gene Reference Data
Alternate Names
IKBA; MAD-3; NFKBI
Description (Vector)
NFKBIA encodes a member of the NF-kappa-B inhibitor family, which contain multiple ankrin repeat domains. The encoded protein interacts with REL dimers to inhibit NF-kappa-B/REL complexes which are involved in inflammatory responses. The encoded protein moves between the cytoplasm and the nucleus via a nuclear localization signal and CRM1-mediated nuclear export. Mutations in this gene have been found in ectodermal dysplasia anhidrotic with T-cell immunodeficiency autosomal dominant disease.
Gene ID
4792
Gene Name (Vector)
NFKB inhibitor alpha
Gene Symbol
NFKBIA
HGNC ID
HGNC:7797
ORF Size (aa)
954
ORF Size (bp)
954 bp
RefSeq ID
NM_020529
RefSeq Synonyms
NM_020529, BC004983, BC002601,
Species
human
UniGene ID
Hs.81328
Related Citations
- Nucleus accumbens inflammation mediates anxiodepressive behavior and compulsive sucrose seeking elicited by saturated dietary fat. L Décarie-Spain, etc, (2018), Molecular Metabolism
- Uremic Advanced Glycation End Products and Protein-Bound Solutes Induce Endothelial Dysfunction Through Suppression of Krüppel-Like Factor 2.. K Saum, etc, (2018), J Am Heart Assoc.
- EphA2 stimulates VCAM-1 expression through calcium-dependent NFAT1 activity. SD Funk, etc, (2018), Cellular Signalling
- Synergistic gene expression during the acute phase response is characterized by transcription factor assisted loading. I Goldstein, etc, (2017), Nature Communicationsvolume
- Protective effects of Nebivolol against interleukin-1ß (IL-1ß)-induced type II collagen destruction mediated by matrix metalloproteinase-13 (MMP-13). Li Z, etc, (2017), Cell Stress and Chaperones
- Caspase-9b interacts directly with cIAP1 to drive agonist-independent activation of NF-¿B and lung tumorigenesis. NT Vu, etc, (2016), Cancer Research
- S-adenosylhomocysteine induces inflammation through NFkB: A possible role for EZH2 in endothelial cell activation. Madalena Barroso, etc, (2016), Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
- The I¿B Kinase Complex Is Required for Plexin-B-Mediated Activation of RhoA. Matthias Zielonka, etc, (2014), PLOS One
- Tumor necrosis factor-a-mediated suppression of dual-specificity phosphatase 4: crosstalk between NF¿B and MAPK regulates endothelial cell survival. Kao, DD. etc, (2013), Molecular and Cellular Biochemistry
- Oxidized Hemoglobin Is An Endogenous Proinflammatory Agonist That Targets Vascular Endothelial Cells. Silva G, etc, (2009), J. Biol. Chem
- The Receptor Interacting Protein 1 Inhibits p53 Induction through NF-¿B Activation and Confers a Worse Prognosis in Glioblastoma. Seongmi Park, (2009), Cancer Research
- Tnf Activates An Irf1-Dependent Autocrine Loop Leading To Sustained Expression Of Chemokines And Stat1-Dependent Type I Interferon¿Response Genes. Yarilina, A., etc., (2008), Nature Immunology
- Vorinostat And Sorafenib Increase Er Stress, Autophagy And Apoptosis Via Ceramide-Dependent Cd95 And Perk Activation. Park MA, etc, (2008), Cancer Biol Ther
- Elevated Toll-Like Receptor 4 Expression And Signaling In Muscle From Insulin-Resistant Subjects. Reyna SM, etc, (2008), Diabetes
- Vorinostat And Sorafenib Synergistically Kill Tumor Cells Via Flip Suppression And Cd95 Activation. Zhang, G., etc., (2008), Clinical Cancer Research
- Human Chorionic Gonadotropin (Hcg) Modulates Prostate Cancer Cell Survival After Irradiation Or Hmg Coa Reductase Inhibitor Treatment. Yacoub, A., etc., (2007), Molecular Pharmacology Fast Forward
- Overexpression Of Myofibrillogenesis Regulator-1 Aggravates Cardiac Hypertrophy Induced By Angiotensin Ii In Mice. Li, H., etc., (2007), Hypertension
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.