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human CENPJ Over-expression AAV

Name 
AAV-h-CENPJ
Cat No 
AAV-204960
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human CENPJ.

AAV-204960
AAV-h-CENPJ

Ready-to-use AAV expressing Human CENPJ (centromere protein J). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
BM032; CENP-J; centromere protein J; centrosomal P4.1-associated protein; CPAP; LAG-3-associated protein; LAP; LIP1; LYST-interacting protein 1; LYST-interacting protein LIP1; LYST-interacting protein LIP7; MCPH6; Sas-4; SASS4; SCKL4
Description (eCommerce)
CENP-J is a centromeric protein that has been reported to play a role in mitosis and transcription. CENP-J plays a role in normal spindle morphology, transcription, cell signaling, and lysosomal trafficking. CENP-J is reported to be an inhibitor of microtubule assembly and may function to regulate microtubule dynamics at the centrosomes. In transcription, CENP-J functions as a coactivator in Stat5- and NF-kappaB-mediated transcription. Mutations in CENP-J are associated with autosomal recessive microcephaly.
Description (Vector)
CENPJ encodes a protein that belongs to the centromere protein family. During cell division, this protein plays a structural role in the maintenance of centrosome integrity and normal spindle morphology, and it is involved in microtubule disassembly at the centrosome. This protein can function as a transcriptional coactivator in the Stat5 signaling pathway, and also as a coactivator of NF-kappaB-mediated transcription, likely via its interaction with the coactivator p300/CREB-binding protein. Mutations in this gene are associated with primary autosomal recessive microcephaly, a disorder characterized by severely reduced brain size and mental retardation. Alternatively spliced transcript variants have been found for this gene.
Gene ID
55835
Gene Name (eCommerce)
centromere protein J
Gene Name (Vector)
centromere protein J
Gene Symbol
CENPJ
HGNC ID
HGNC:17272
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
4017
ORF Size (bp)
4017 bp
Protein Name (eCommerce)
Centromere protein J
RefSeq ID
NM_018451
RefSeq Synonyms
NM_018451, BC113664, BC113662, BC113111, BC113110,
Research Areas
Cell Cycle,Cell Division,Cytoskeleton,Neurobiology,Prolactin Signaling,Replication,Signal Transduction
Research Areas (Faceted)
cell_biology,cell_cycle,genetics,neurobiology,signal_transduction
Species
human
Target Sentence
CENP-J is a centromeric protein that has been reported to play a role in mitosis and transcription. CENP-J plays a role in normal spindle morphology, transcription, cell signaling, and lysosomal trafficking. CENP-J is reported to be an inhibitor of microtubule assembly and may function to regulate microtubule dynamics at the centrosomes. In transcription, CENP-J functions as a coactivator in Stat5- and NF-kappaB-mediated transcription. Mutations in CENP-J are associated with autosomal recessive microcephaly.
UniGene ID
Hs.513379
UniProt ID (eCommerce)
Q9HC77

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.