Promotional banner reading 'FALL SAVINGS' with expiry date August 31 on an orange background; features a group of people with orange stacked blocks on the right and discounts for services and catalog products.

human CENPJ shRNA silencing AAV

Name 
AAV-h-CENPJ-shRNA
Cat No 
shAAV-204959
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human CENPJ.

shAAV-204959
AAV-h-CENPJ-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human CENPJ (centromere protein J). Available with optional GFP reporter or cell-specific promoter.

Request a Quote

Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
70
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
BM032; CENP-J; centromere protein J; centrosomal P4.1-associated protein; CPAP; LAG-3-associated protein; LAP; LIP1; LYST-interacting protein 1; LYST-interacting protein LIP1; LYST-interacting protein LIP7; MCPH6; Sas-4; SASS4; SCKL4
Description (eCommerce)
CENP-J is a centromeric protein that has been reported to play a role in mitosis and transcription. CENP-J plays a role in normal spindle morphology, transcription, cell signaling, and lysosomal trafficking. CENP-J is reported to be an inhibitor of microtubule assembly and may function to regulate microtubule dynamics at the centrosomes. In transcription, CENP-J functions as a coactivator in Stat5- and NF-kappaB-mediated transcription. Mutations in CENP-J are associated with autosomal recessive microcephaly.
Description (Vector)
CENPJ encodes a protein that belongs to the centromere protein family. During cell division, this protein plays a structural role in the maintenance of centrosome integrity and normal spindle morphology, and it is involved in microtubule disassembly at the centrosome. This protein can function as a transcriptional coactivator in the Stat5 signaling pathway, and also as a coactivator of NF-kappaB-mediated transcription, likely via its interaction with the coactivator p300/CREB-binding protein. Mutations in this gene are associated with primary autosomal recessive microcephaly, a disorder characterized by severely reduced brain size and mental retardation. Alternatively spliced transcript variants have been found for this gene.
Gene ID
55835
Gene Name (eCommerce)
centromere protein J
Gene Name (Vector)
centromere protein J
Gene Symbol
CENPJ
HGNC ID
HGNC:17272
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
4017
ORF Size (bp)
4017 bp
Protein Name (eCommerce)
Centromere protein J
RefSeq ID
NM_018451
RefSeq Synonyms
NM_018451, BC113664, BC113662, BC113111, BC113110,
Research Areas
Cell Cycle,Cell Division,Cytoskeleton,Neurobiology,Prolactin Signaling,Replication,Signal Transduction
Research Areas (Faceted)
cell_biology,cell_cycle,genetics,neurobiology,signal_transduction
Species
human
Target Sentence
CENP-J is a centromeric protein that has been reported to play a role in mitosis and transcription. CENP-J plays a role in normal spindle morphology, transcription, cell signaling, and lysosomal trafficking. CENP-J is reported to be an inhibitor of microtubule assembly and may function to regulate microtubule dynamics at the centrosomes. In transcription, CENP-J functions as a coactivator in Stat5- and NF-kappaB-mediated transcription. Mutations in CENP-J are associated with autosomal recessive microcephaly.
UniGene ID
Hs.513379
UniProt ID (eCommerce)
Q9HC77

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.