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human CASP1 Over-expression AAV

Name 
AAV-h-CASP1
Cat No 
AAV-204110
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human CASP1.

AAV-204110
AAV-h-CASP1

Ready-to-use AAV expressing Human CASP1 (caspase 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
ICE; IL1BC; P45
Description (Vector)
CASP1 encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce 2 subunits, large and small, that dimerize to form the active enzyme. CASP1 was identified by its ability to proteolytically cleave and activate the inactive precursor of interleukin-1, a cytokine involved in the processes such as inflammation, septic shock, and wound healing. CASP1 has been shown to induce cell apoptosis and may function in various developmental stages. Studies of a similar gene in mouse suggest a role in the pathogenesis of Huntington disease. Alternative splicing results in transcript variants encoding distinct isoforms.
Gene ID
834
Gene Name (Vector)
caspase 1
Gene Symbol
CASP1
HGNC ID
HGNC:1499
ORF Size (aa)
936
ORF Size (bp)
936 bp
RefSeq ID
NM_001223
RefSeq Synonyms
NM_033295, NM_033294, NM_033293, NM_033292, NM_001257119, NM_001257118, NM_001223, BC062327,
Species
human
UniGene ID
Hs.2490

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.