human CASP1 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human CASP1.
shADV-204110
Ad-h-CASP1-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human CASP1 (caspase 1). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
ICE; IL1BC; P45
Description (Vector)
CASP1 encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce 2 subunits, large and small, that dimerize to form the active enzyme. CASP1 was identified by its ability to proteolytically cleave and activate the inactive precursor of interleukin-1, a cytokine involved in the processes such as inflammation, septic shock, and wound healing. CASP1 has been shown to induce cell apoptosis and may function in various developmental stages. Studies of a similar gene in mouse suggest a role in the pathogenesis of Huntington disease. Alternative splicing results in transcript variants encoding distinct isoforms.
Gene ID
834
Gene Name (Vector)
caspase 1
Gene Symbol
CASP1
HGNC ID
HGNC:1499
ORF Size (aa)
936
ORF Size (bp)
936 bp
RefSeq ID
NM_001223
RefSeq Synonyms
NM_033295, NM_033294, NM_033293, NM_033292, NM_001257119, NM_001257118, NM_001223, BC062327,
Species
human
UniGene ID
Hs.2490
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.