human ZFHX3 Adenovirus

Name
Ad-h-ZFHX3

Cat No
ADV-233062

Availability
4-5 weeks

This is an Adenovirus expressing Human ZFHX3.

ADV-233062

Ad-h-ZFHX3

Ready-to-use Adenovirus expressing Human ZFHX3 (zinc finger homeobox 3). Available with optional GFP reporter or cell-specific promoter.

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Vector Designer

Product Details

Promoter

CMV

Reporter

none, optional GFP, CFP, YFP, RFP or mCherry

Storage Buffer

DMEM, 2% BSA, 2.5% Glycerol

Viral Backbone

Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names

ATBF1; ATBT; ZNF927

Description (Vector)

ZFHX3 encodes a transcription factor with multiple homeodomains and zinc finger motifs, and regulates myogenic and neuronal differentiation. The encoded protein suppresses expression of the alpha-fetoprotein gene by binding to an AT-rich enhancer motif. The protein has also been shown to negatively regulate c-Myb, and transactivate the cell cycle inhibitor cyclin-dependent kinase inhibitor 1A (also known as p21CIP1). ZFHX3 is reported to function as a tumor suppressor in several cancers, and sequence variants of this gene are also associated with atrial fibrillation. Multiple transcript variants expressed from alternate promoters and encoding different isoforms have been found for this gene.

Gene ID

463

Gene Name (Vector)

zinc finger homeobox 3

Gene Symbol

ZFHX3

HGNC ID

HGNC:777

ORF Size (aa)

2661

ORF Size (bp)

2661 bp

RefSeq ID

NM_006885

RefSeq Synonyms

NM_006885, NM_001164766, BC029653,

Species

human

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.