human CNOT1 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human CNOT1.
shAAV-205603
AAV-h-CNOT1-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human CNOT1 (CCR4-NOT transcription complex subunit 1). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
AD-005; adrenal gland protein AD-005; CCR4-associated factor 1; CCR4-NOT transcription complex subunit 1; CDC39; hNOT1; negative regulator of transcription subunit 1 homolog; NOT1; NOT1 (negative regulator of transcription 1, yeast) homolog; NOT1H
Description (eCommerce)
Scaffolding component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Its scaffolding function implies its interaction with the catalytic complex module and diverse RNA-binding proteins mediating the complex recruitment to selected mRNA 3'UTRs. Involved in degradation of AU-rich element (ARE)-containing mRNAs probably via association with ZFP36. Mediates the recruitment of the CCR4-NOT complex to miRNA targets and to the RISC complex via association with TNRC6A, TNRC6B or TNRC6C. Acts as a transcriptional repressor. Represses the ligand-dependent transcriptional activation by nuclear receptors. Involved in the maintenance of emryonic stem (ES) cell identity. [taken from NCBI Entrez Gene (Gene ID: 23019)]. [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/A5YKK6].
Gene ID
23019
Gene Name (eCommerce)
CCR4-NOT transcription complex subunit 1
Gene Name (Vector)
CCR4-NOT transcription complex subunit 1
Gene Symbol
CNOT1
HGNC ID
HGNC:7877
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
4656
ORF Size (bp)
4656 bp
Protein Name (eCommerce)
CCR4-NOT transcription complex subunit 1
RefSeq ID
NM_016284
RefSeq Synonyms
NM_206999, NM_016284, NM_001265612, BC040523,
Research Areas
Gene Expression,RNA Processing,Transcription Factor/Regulator,Translational Control
Research Areas (Faceted)
cell_biology,genetics,transcription_translation
Species
human
Target Sentence
Scaffolding component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Its scaffolding function implies its interaction with the catalytic complex module and diverse RNA-binding proteins mediating the complex recruitment to selected mRNA 3'UTRs. Involved in degradation of AU-rich element (ARE)-containing mRNAs probably via association with ZFP36. Mediates the recruitment of the CCR4-NOT complex to miRNA targets and to the RISC complex via association with TNRC6A, TNRC6B or TNRC6C. Acts as a transcriptional repressor. Represses the ligand-dependent transcriptional activation by nuclear receptors. Involved in the maintenance of emryonic stem (ES) cell identity. [taken from NCBI Entrez Gene (Gene ID: 23019)]. [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/A5YKK6].
UniGene ID
Hs.716474
UniProt ID (eCommerce)
A5YKK6
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.