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human PEG10 Adenovirus

Name 
Ad-h-PEG10
Cat No 
ADV-218604
Availability
4-5 weeks
Categories
Adenovirus, Over-Expression

This is an Adenovirus expressing Human PEG10.

ADV-218604
Ad-h-PEG10

Ready-to-use Adenovirus expressing Human PEG10 (paternally expressed 10). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
CMV
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
EDR; embryonal carcinoma differentiation regulated; Embryonal carcinoma differentiation-regulated protein; HB-1; mammalian retrotransposon-derived 2; mammalian retrotransposon-derived protein 2; Mar2; Mart2; MEF3 like 1; MEF3L; MEF3-like protein 1; myelin expression factor 3-like protein 1; paternally expressed gene 10 protein; retrotransposon gag domain-containing protein 3; retrotransposon Gag like 2; retrotransposon-derived gag-like polyprotein; retrotransposon-derived protein PEG10; RGAG3; RTL2; SIRH1; Sushi-Ichi retrotransposon homolog 1; ty3/Gypsy-like protein
Description (eCommerce)
Retrotransposon-derived protein PEG10 prevents apoptosis in hepatocellular carcinoma (HCC) cells through interaction with SIAH1, a mediator of apoptosis. PEG10 may also have a role in cell growth promotion and hepatoma formation. It inhibits the TGF-beta signaling by interacting with the TGF-beta receptor ALK1 [taken from UniProtKB (Entry: Q86TG7)].
Description (Vector)
This is a paternally expressed imprinted gene that encodes transcripts containing two overlapping open reading frames (ORFs), RF1 and RF1/RF2, as well as retroviral-like slippage and pseudoknot elements, which can induce a -1 nucleotide frame-shift. ORF1 encodes a shorter isoform with a CCHC-type zinc finger motif containing a sequence characteristic of gag proteins of most retroviruses and some retrotransposons. The longer isoform is the result of -1 translational frame-shifting leading to translation of a gag/pol-like protein combining RF1 and RF2. It contains the active-site consensus sequence of the protease domain of pol proteins. Additional isoforms resulting from alternatively spliced transcript variants, as well as from use of upstream non-AUG (CUG) start codon, have been reported for this gene. Increased expression of this gene is associated with hepatocellular carcinomas.
Gene ID
23089
Gene Name (eCommerce)
paternally expressed 10
Gene Name (Vector)
paternally expressed 10
Gene Symbol
PEG10
HGNC ID
HGNC:14005
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
978
Protein Name (eCommerce)
Retrotransposon-derived protein PEG10
RefSeq ID
NM_001040152
RefSeq Synonyms
NM_015068, NM_001184962, NM_001184961, NM_001172438, NM_001172437, NM_001040152, BC050659,
Research Areas
Apoptosis,Zinc-finger
Research Areas (Faceted)
cell_biology
Species
human
Target Sentence
Retrotransposon-derived protein PEG10 prevents apoptosis in hepatocellular carcinoma (HCC) cells through interaction with SIAH1, a mediator of apoptosis. PEG10 may also have a role in cell growth promotion and hepatoma formation. It inhibits the TGF-beta signaling by interacting with the TGF-beta receptor ALK1 [taken from UniProtKB (Entry: Q86TG7)].
UniGene ID
Hs.147492
UniProt ID (eCommerce)
Q86TG7

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.