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human BUB1B Adenovirus

Name 
Ad-h-BUB1B
Cat No 
ADV-202356
Availability
4-5 weeks
Categories
Adenovirus, Over-Expression

This is an Adenovirus expressing Human BUB1B.

ADV-202356
Ad-h-BUB1B

Ready-to-use Adenovirus expressing Human BUB1B (BUB1 mitotic checkpoint serine/threonine kinase B). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
CMV
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
Bub1A; BUB1B, mitotic checkpoint serine/threonine kinase; BUB1beta; BUBR1; budding uninhibited by benzimidazoles 1 homolog beta; hBUBR1; MAD3/BUB1-related protein kinase; MAD3L; mitotic checkpoint kinase MAD3L; mitotic checkpoint serine/threonine-protein kinase BUB1 beta; MVA1; Protein SSK1; SSK1
Description (eCommerce)
BubR1 is cell cycle checkpoint kinase and component of the spindle checkpoint machinery. BubR1 and other spindle checkpoint proteins ensure that segregation does not proceed until all replicated chromatids are associated with a functional bipolar spindle. BubR1 is part of the mitotic checkpoint complex that also includes Bub3, Mad2, and Cdc20. In this trimer BubR1 functions to inhibit the anaphase promoting complex (APC) that promotes chromosome segregation. BubR1 is suggested to be a paralog of Bub1.
Description (Vector)
BUB1B encodes a kinase involved in spindle checkpoint function. The protein has been localized to the kinetochore and plays a role in the inhibition of the anaphase-promoting complex/cyclosome (APC/C), delaying the onset of anaphase and ensuring proper chromosome segregation. Impaired spindle checkpoint function has been found in many forms of cancer.
Gene ID
701
Gene Name (eCommerce)
BUB1 mitotic checkpoint serine/threonine kinase B
Gene Name (Vector)
BUB1 mitotic checkpoint serine/threonine kinase B
Gene Symbol
BUB1B
HGNC ID
HGNC:1149
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
3153
ORF Size (bp)
3153 bp
Protein Name (eCommerce)
Mitotic checkpoint serine/threonine-protein kinase BUB1 beta
RefSeq ID
NM_001211
RefSeq Synonyms
NM_001211, BC018739,
Research Areas
Aging,Apoptosis,Cancer,Cell Cycle,Cell Division,Cytoskeleton,Host-Virus Interactions,Kinase/Phosphatase,PLK1 Signaling,Signal Transduction,Tumor Suppressors/Oncoproteins
Research Areas (Faceted)
cancer,cell_biology,cell_cycle,genetics,infectious_disease,signal_transduction
Species
human
Target Sentence
BubR1 is cell cycle checkpoint kinase and component of the spindle checkpoint machinery. BubR1 and other spindle checkpoint proteins ensure that segregation does not proceed until all replicated chromatids are associated with a functional bipolar spindle. BubR1 is part of the mitotic checkpoint complex that also includes Bub3, Mad2, and Cdc20. In this trimer BubR1 functions to inhibit the anaphase promoting complex (APC) that promotes chromosome segregation. BubR1 is suggested to be a paralog of Bub1.
UniGene ID
Hs.631699
UniProt ID (eCommerce)
O60566

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About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.