rat CDKN1A Over-expression AAV

Name
AAV-r-CDKN1A

Cat No
AAV-294363

Availability
4-5 weeks

This is an AAV expressing Rat Cdkn1a.

AAV-294363

AAV-r-CDKN1A

Ready-to-use AAV expressing Rat Cdkn1a (cyclin-dependent kinase inhibitor 1A). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

CMV (default), or choose from 30 different ubiquitous or cell specific promoter

Reporter

none, optional GFP, CFP, YFP, RFP or mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

Cip1; UV96; Waf1

Description (Vector)

CDKN1A may be the important intermediate by which p53/TP53 mediates its role as an inhibitor of cellular proliferation in response to DNA damage. Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression. Functions in the nuclear localization and assembly of cyclin D-CDK4 complex and promotes its kinase activity towards RB1. At higher stoichiometric ratios, inhibits the kinase activity of the cyclin D-CDK4 complex.

Gene ID

114851

Gene Name (Vector)

cyclin-dependent kinase inhibitor 1A

Gene Symbol

Cdkn1a

ORF Size (aa)

495

ORF Size (bp)

495 bp

RefSeq ID

NM_080782

RefSeq Synonyms

NM_080782, BC100620,

Species

rat

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.