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mouse SETD7 Over-expression AAV

Name 
AAV-m-SETD7
Cat No 
AAV-281082
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Mouse Setd7.

AAV-281082
AAV-m-SETD7

Ready-to-use AAV expressing Mouse Setd7 (SET domain containing (lysine methyltransferase) 7). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
1600028F23Rik; H3K4MT; KMT7; mKIAA1717; Set7; Set7/9
Description (Vector)
Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes such as collagenase or insulin. Recruited by IPF1/PDX-1 to the insulin promoter, leading to activate transcription. Has also methyltransferase activity toward non-histone proteins such as p53/TP53, TAF10, and possibly TAF7 by recognizing and binding the [KR]-[STA]-K in substrate proteins. Monomethylates 'Lys-189' of TAF10, leading to increase the affinity of TAF10 for RNA polymerase II. Monomethylates 'Lys-372' of p53/TP53, stabilizing p53/TP53 and increasing p53/TP53-mediated transcriptional activation.
Gene ID
73251
Gene Name (Vector)
SET domain containing (lysine methyltransferase) 7
Gene Symbol
Setd7
ORF Size (aa)
1101
ORF Size (bp)
1101 bp
RefSeq ID
NM_080793
RefSeq Synonyms
NM_080793, BC050190,
Species
mouse
UniGene ID
Mm.192111

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.