mouse WWTR1 Over-expression AAV
This is an AAV expressing Mouse Wwtr1.
AAV-276356
AAV-m-WWTR1
Ready-to-use AAV expressing Mouse Wwtr1 (WW domain containing transcription regulator 1). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
2310058J06Rik; 2610021I22Rik; C78399; Taz
Description (Vector)
Transcriptional coactivator which acts as a downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. WWTR1 enhances PAX8 and NKX2-1/TTF1-dependent gene activation. Regulates the nuclear accumulation of SMADS and has a key role in coupling them to the transcriptional machinery such as the mediator complex. Regulates embryonic stem-cell self-renewal, promotes cell proliferation and epithelial-mesenchymal transition.
Gene ID
97064
Gene Name (Vector)
WW domain containing transcription regulator 1
Gene Symbol
Wwtr1
ORF Size (aa)
1188
RefSeq ID
NM_133784
RefSeq Synonyms
NM_133784, NM_001168281, BC014727, BC004640,
Species
mouse
UniGene ID
Mm.405029
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.