rat WWTR1 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Rat Wwtr1.
shADV-294011
Ad-r-WWTR1-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Rat Wwtr1 (WW domain containing transcription regulator 1). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Description (Vector)
Transcriptional coactivator which acts as a downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. WWTR1 enhances PAX8 and NKX2-1/TTF1-dependent gene activation. Regulates the nuclear accumulation of SMADS and has a key role in coupling them to the transcriptional machinery such as the mediator complex. Regulates embryonic stem-cell self-renewal, promotes cell proliferation and epithelial-mesenchymal transition.
Gene ID
295062
Gene Name (Vector)
WW domain containing transcription regulator 1
Gene Symbol
Wwtr1
ORF Size (aa)
1188
RefSeq ID
NM_001024869
RefSeq Synonyms
NM_001024869, BC097968,
Species
rat
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.