human CD40 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human CD40.
shADV-204653
Ad-h-CD40-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human CD40 (CD40 molecule). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
B cell surface antigen CD40; B cell-associated molecule; B-cell surface antigen CD40; Bp50; CD antigen CD40; CD40 molecule, TNF receptor superfamily member 5; CD40L receptor; CDW40; p50; TNFRSF5; tumor necrosis factor receptor superfamily member 5
Description (eCommerce)
CD40 is a member of the TNF-receptor superfamily. It is a receptor on antigen-presenting cells of the immune system and is essential for mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. [provided by RefSeq, Nov 2014] [taken from NCBI Entrez Gene (Gene ID: 958)].
Description (Vector)
CD40 is a member of the TNF-receptor superfamily. This receptor has been found to be essential in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of this receptor and its ligand, which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with this receptor and serves as a mediator of the signal transduction. The interaction of this receptor and its ligand is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.
Gene ID
958
Gene Name (eCommerce)
CD40 molecule
Gene Name (Vector)
CD40 molecule
Gene Symbol
CD40
HGNC ID
HGNC:11919
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
834
ORF Size (bp)
834 bp
Protein Name (eCommerce)
Tumor necrosis factor receptor superfamily member 5
RefSeq ID
NM_001250
RefSeq Synonyms
NM_152854, NM_001322422, NM_001322421, NM_001302753, NM_001250, BC064518, BC012419,
Research Areas
Apoptosis,Cancer,Cardiology,Cardiovascular,CD40 Signaling,Host-Virus Interactions,Immunology,Interleukin Signaling,NF-kB Signaling,Signal Transduction,Toll-like Receptor Signaling,Transcriptional Misregulation in Cancer
Research Areas (Faceted)
cancer,signal_transduction,cell_biology,cardiovascular,signal_transduction,immunology,infectious_disease,immunology,signal_transduction,cancer,transcription_translation
Species
human
Target Sentence
CD40 is a member of the TNF-receptor superfamily. It is a receptor on antigen-presenting cells of the immune system and is essential for mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. [provided by RefSeq, Nov 2014] [taken from NCBI Entrez Gene (Gene ID: 958)].
UniGene ID
Hs.472860
UniProt ID (eCommerce)
P25942
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.