mouse NOX4 Over-expression AAV

Name 
AAV-m-NOX4
Cat No 
AAV-265956
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Mouse Nox4.

AAV-265956
AAV-m-NOX4

Ready-to-use AAV expressing Mouse Nox4 (NADPH oxidase 4). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
AI648021
Description (Vector)
Constitutive NADPH oxidase which generates superoxide intracellularly upon formation of a complex with CYBA/p22phox. Regulates signaling cascades probably through phosphatases inhibition. May function as an oxygen sensor regulating the KCNK3/TASK-1 potassium channel and HIF1A activity. May regulate insulin signaling cascade. May play a role in apoptosis, bone resorption and lipolysaccharide-mediated activation of NFKB. May produce superoxide in the nucleus and play a role in regulating gene expression upon cell stimulation. Isoform 3 is not functional. Isoform 4 displays an increased activity. Isoform 5 and isoform 6 display reduced activity.
Gene ID
50490
Gene Name (Vector)
NADPH oxidase 4
Gene Symbol
Nox4
ORF Size (aa)
1737
ORF Size (bp)
1737 bp
RefSeq ID
NM_015760
RefSeq Synonyms
NM_015760, NM_001285835, NM_001285833, BC165954, BC138918,
Species
mouse
UniGene ID
Mm.31748

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.