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mouse MIB1 Over-expression AAV

Name 
AAV-m-MIB1
Cat No 
AAV-264620
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Mouse Mib1.

AAV-264620
AAV-m-MIB1

Ready-to-use AAV expressing Mouse Mib1 (mindbomb E3 ubiquitin protein ligase 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
DIP-1; E430019M12Rik; Mib; mKIAA1323
Description (Vector)
E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors. Probably mediates ubiquitination and subsequent proteasomal degradation of DAPK1, thereby antagonizing anti-apoptotic effects of DAPK1 to promote TNF-induced apoptosis (By similarity). Mediates 'Lys-63'-linked polyubiquitination of TBK1, which probably participates in kinase activation.
Gene ID
225164
Gene Name (Vector)
mindbomb E3 ubiquitin protein ligase 1
Gene Symbol
Mib1
ORF Size (aa)
3021
ORF Size (bp)
3021 bp
RefSeq ID
NM_144860
RefSeq Synonyms
NM_144860, BC131662,
Species
mouse
UniGene ID
Mm.21500

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.