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mouse MIB1 shRNA silencing AAV

Name 
AAV-m-MIB1-shRNA
Cat No 
shAAV-264620
Availability
6-8 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Mouse Mib1.

shAAV-264620
AAV-m-MIB1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Mouse Mib1 (mindbomb E3 ubiquitin protein ligase 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
DIP-1; E430019M12Rik; Mib; mKIAA1323
Description (Vector)
E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors. Probably mediates ubiquitination and subsequent proteasomal degradation of DAPK1, thereby antagonizing anti-apoptotic effects of DAPK1 to promote TNF-induced apoptosis (By similarity). Mediates 'Lys-63'-linked polyubiquitination of TBK1, which probably participates in kinase activation.
Gene ID
225164
Gene Name (Vector)
mindbomb E3 ubiquitin protein ligase 1
Gene Symbol
Mib1
ORF Size (aa)
3021
ORF Size (bp)
3021 bp
RefSeq ID
NM_144860
RefSeq Synonyms
NM_144860, BC131662,
Species
mouse
UniGene ID
Mm.21500

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.