mouse MIB1 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Mouse Mib1.
shADV-264620
Ad-m-MIB1-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Mouse Mib1 (mindbomb E3 ubiquitin protein ligase 1). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
DIP-1; E430019M12Rik; Mib; mKIAA1323
Description (Vector)
E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors. Probably mediates ubiquitination and subsequent proteasomal degradation of DAPK1, thereby antagonizing anti-apoptotic effects of DAPK1 to promote TNF-induced apoptosis (By similarity). Mediates 'Lys-63'-linked polyubiquitination of TBK1, which probably participates in kinase activation.
Gene ID
225164
Gene Name (Vector)
mindbomb E3 ubiquitin protein ligase 1
Gene Symbol
Mib1
ORF Size (aa)
3021
ORF Size (bp)
3021 bp
RefSeq ID
NM_144860
RefSeq Synonyms
NM_144860, BC131662,
Species
mouse
UniGene ID
Mm.21500
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.