mouse GABBR2 Over-expression AAV

Name 
AAV-m-GABBR2
Cat No 
AAV-259790
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Mouse Gabbr2.

AAV-259790
AAV-m-GABBR2

Ready-to-use AAV expressing Mouse Gabbr2 (gamma-aminobutyric acid (GABA) B receptor, 2). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
GABABR2; Gb2; Gm425; Gpr51
Description (Vector)
Receptor for GABA. The activity of this receptor is mediated by G-proteins that inhibit adenylyl cyclase activity, stimulates phospholipase A2, activates potassium channels, inactivates voltage-dependent calcium-channels and modulates inositol phospholipids hydrolysis. Plays a critical role in the fine-tuning of inhibitory synaptic transmission. Pre-synaptic GABA-B-R inhibit neurotransmitter release by down-regulating high-voltage activated calcium channels, whereas postsynaptic GABA-B-R decrease neuronal excitability by activating a prominent inwardly rectifying potassium (Kir) conductance that underlies the late inhibitory postsynaptic potentials. Not only implicated in synaptic inhibition but also in hippocampal long-term potentiation, slow wave sleep, muscle relaxation and antinociception.
Gene ID
242425
Gene Name (Vector)
gamma-aminobutyric acid (GABA) B receptor, 2
Gene Symbol
Gabbr2
ORF Size (aa)
2820
ORF Size (bp)
2820 bp
RefSeq ID
NM_001081141
RefSeq Synonyms
NM_001081141, BC156988, BC156087,
Species
mouse
UniGene ID
Mm.101909

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.