mouse CD86 Over-expression AAV
This is an AAV expressing Mouse Cd86.
AAV-255056
AAV-m-CD86
Ready-to-use AAV expressing Mouse Cd86 (CD86 antigen). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
activation B7-2 antigen; B7; B7.2; B70; B7-2; CD antigen CD86; Cd28l2; CLS1; early T cell costimulatory molecule-1; Early T-cell costimulatory molecule 1; ETC-1; Ly58; Ly-58; MB7; MB7-2; T-lymphocyte activation antigen CD86; TS/A-2
Description (eCommerce)
CD86 is a type I membrane protein that is a member of the immunoglobulin superfamily. CD86 is expressed by antigen-presenting cells, and it is the ligand for two proteins at the cell surface of T cells, CD28 antigen and cytotoxic T-lymphocyte-associated protein 4. Binding of CD86 with CD28 antigen is a costimulatory signal for activation of the T-cell. Binding of CD86 with cytotoxic T-lymphocyte-associated protein 4 negatively regulates T-cell activation and diminishes the immune response [taken from NCBI Entrez Gene (Gene ID: 942)].
Description (Vector)
Receptor involved in the costimulatory signal essential for T-lymphocyte proliferation and interleukin-2 production, by binding CD28 or CTLA-4. May play a critical role in the early events of T-cell activation and costimulation of naive T-cells, such as deciding between immunity and anergy that is made by T-cells within 24 hours after activation. Isoform 2 interferes with the formation of CD86 clusters, and thus acts as a negative regulator of T-cell activation.
Gene ID
12524
Gene Name (eCommerce)
CD86 antigen
Gene Name (Vector)
CD86 antigen
Gene Symbol
Cd86
NCBI Taxonomy ID (eCommerce)
10090.0
ORF Size (aa)
930
Protein Name (eCommerce)
T-lymphocyte activation antigen CD86
RefSeq ID
NM_019388
RefSeq Synonyms
NM_019388, BC013807,
Research Areas
B Cell Receptor Signaling,Cancer,Cardiology,Cardiovascular,EGFR Signaling,EGFR Signaling in Cancer,Fc Receptor Signaling,FGF Signaling,GPCR Signaling,Host-Virus Interactions,Immunology,Innate Immunity,Interleukin Signaling,Neurobiology,NF-kB Signaling,NGF Signaling,PDGF Signaling,PI3K/Akt Signaling,PI3K-AKT Signaling in Cancer,SCF-KIT Signaling,Signal Transduction,T Cell Receptor Signaling,Toll-like Receptor Signaling,Transcriptional Misregulation in Cancer
Research Areas (Faceted)
cancer,cardiovascular,immunology,infectious_disease,neurobiology,signal_transduction,stem_cell_biology,transcription_translation
Species
mouse
Target Sentence
CD86 is a type I membrane protein that is a member of the immunoglobulin superfamily. CD86 is expressed by antigen-presenting cells, and it is the ligand for two proteins at the cell surface of T cells, CD28 antigen and cytotoxic T-lymphocyte-associated protein 4. Binding of CD86 with CD28 antigen is a costimulatory signal for activation of the T-cell. Binding of CD86 with cytotoxic T-lymphocyte-associated protein 4 negatively regulates T-cell activation and diminishes the immune response [taken from NCBI Entrez Gene (Gene ID: 942)].
UniGene ID
Mm.1452
UniProt ID (eCommerce)
P42082
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.