human CD86 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human CD86.
shAAV-204693
AAV-h-CD86-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human CD86 (CD86 molecule). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
Activation B7-2 antigen; B7.2; B70; B7-2; B-lymphocyte activation antigen B7-2; BU63; CD antigen CD86; CD28LG2; CD86 antigen (CD28 antigen ligand 2, B7-2 antigen); CTLA-4 counter-receptor B7.2; FUN-1; LAB72; T-lymphocyte activation antigen CD86
Description (eCommerce)
CD86 is a type I membrane protein that is a member of the immunoglobulin superfamily. CD86 is expressed by antigen-presenting cells, and it is the ligand for two proteins at the cell surface of T cells, CD28 antigen and cytotoxic T-lymphocyte-associated protein 4. Binding of CD86 with CD28 antigen is a costimulatory signal for activation of the T-cell. Binding of CD86 with cytotoxic T-lymphocyte-associated protein 4 negatively regulates T-cell activation and diminishes the immune response [taken from NCBI Entrez Gene (Gene ID: 942)].
Description (Vector)
CD86 encodes a type I membrane protein that is a member of the immunoglobulin superfamily. This protein is expressed by antigen-presenting cells, and it is the ligand for two proteins at the cell surface of T cells, CD28 antigen and cytotoxic T-lymphocyte-associated protein 4. Binding of this protein with CD28 antigen is a costimulatory signal for activation of the T-cell. Binding of this protein with cytotoxic T-lymphocyte-associated protein 4 negatively regulates T-cell activation and diminishes the immune response. Alternative splicing results in several transcript variants encoding different isoforms.
Gene ID
942
Gene Name (eCommerce)
CD86 molecule
Gene Name (Vector)
CD86 molecule
Gene Symbol
CD86
HGNC ID
HGNC:1705
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
990
ORF Size (bp)
990 bp
Protein Name (eCommerce)
T-lymphocyte activation antigen CD86
RefSeq ID
NM_006889
RefSeq Synonyms
NM_176892, NM_175862, NM_006889, NM_001206925, NM_001206924, BC040261,
Research Areas
B-cell Receptor Signaling,Cancer,Cardiology,Cardiovascular,EGFR Signaling,EGFR Signaling in Cancer,Fc Receptor Signaling,FGF Signaling,GPCR Signaling,Host-Virus Interactions,Immunology,Innate Immunity,Interleukin Signaling,Neurobiology,NF-kB Signaling,NGF Signaling,PDGF Signaling,PI3K/Akt Signaling,PI3K-AKT Signaling in Cancer,SCF-KIT Signaling,Signal Transduction,T-cell Receptor Signaling,Toll-like Receptor Signaling,Transcriptional Misregulation in Cancer
Research Areas (Faceted)
cancer,cardiovascular,immunology,infectious_disease,neurobiology,signal_transduction,stem_cell_biology,transcription_translation
Species
human
Target Sentence
CD86 is a type I membrane protein that is a member of the immunoglobulin superfamily. CD86 is expressed by antigen-presenting cells, and it is the ligand for two proteins at the cell surface of T cells, CD28 antigen and cytotoxic T-lymphocyte-associated protein 4. Binding of CD86 with CD28 antigen is a costimulatory signal for activation of the T-cell. Binding of CD86 with cytotoxic T-lymphocyte-associated protein 4 negatively regulates T-cell activation and diminishes the immune response [taken from NCBI Entrez Gene (Gene ID: 942)].
UniGene ID
Hs.171182
UniProt ID (eCommerce)
P42081
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.