human APH1B Over-expression AAV

Name 
AAV-h-APH1B
Cat No 
AAV-230040
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human APH1B.

AAV-230040
AAV-h-APH1B

Ready-to-use AAV expressing Human APH1B (aph-1 homolog B, gamma-secretase subunit). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
APH-1B; PRO1328; PSFL; TAAV688
Description (Vector)
APH1B encodes a multi-pass transmembrane protein that is a functional component of the gamma-secretase complex, which also contains presenilin and nicastrin. This protein represents a stabilizing cofactor for the presenilin holoprotein in the complex. The gamma-secretase complex catalyzes the cleavage of integral proteins such as notch receptors and beta-amyloid precursor protein.
Gene ID
83464
Gene Name (Vector)
aph-1 homolog B, gamma-secretase subunit
Gene Symbol
APH1B
HGNC ID
HGNC:24080
ORF Size (aa)
774
ORF Size (bp)
774 bp
RefSeq ID
NM_031301
RefSeq Synonyms
NM_031301, NM_001145646, BC020905,
Species
human
UniGene ID
Hs.511703

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.