human TFRC Over-expression AAV

Name 
AAV-h-TFRC
Cat No 
AAV-225374
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human TFRC.

AAV-225374
AAV-h-TFRC

Ready-to-use AAV expressing Human TFRC (transferrin receptor). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
CD antigen CD71; CD71; IMD46; p90; T9; TFR; TFR1; TR; transferrin receptor protein 1; TRFR
Description (eCommerce)
Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor (TR) into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). A second ligand, the heditary hemochromatosis protein HFE, competes for binding with transferrin for an overlapping C-terminal binding site [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/P02786].
Gene ID
7037
Gene Name (eCommerce)
transferrin receptor
Gene Name (Vector)
transferrin receptor
Gene Symbol
TFRC
HGNC ID
HGNC:11763
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2283
ORF Size (bp)
2283 bp
Protein Name (eCommerce)
Transferrin receptor protein 1
RefSeq ID
NM_003234
RefSeq Synonyms
NM_003234, NM_001313966, NM_001313965, NM_001128148, BC001188,
Research Areas
Aging,EGFR Signaling,Golgi Apparatus,HIF-1 Signaling,Host-Virus Interactions,Hypoxia,Immunology,Mitochondrion,Signal Transduction,T-cell Receptor Signaling,Transport
Research Areas (Faceted)
cell_biology,immunology,infectious_disease,signal_transduction
Species
human
Target Sentence
Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor (TR) into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). A second ligand, the heditary hemochromatosis protein HFE, competes for binding with transferrin for an overlapping C-terminal binding site [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/P02786].
UniGene ID
Hs.529618
UniProt ID (eCommerce)
P02786

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.