human TCL1A Over-expression AAV

Name 
AAV-h-TCL1A
Cat No 
AAV-225227
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human TCL1A.

AAV-225227
AAV-h-TCL1A

Ready-to-use AAV expressing Human TCL1A (T-cell leukemia/lymphoma 1A). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
TCL1
Description (Vector)
Overexpression of the TCL1 gene in humans has been implicated in the development of mature T cell leukemia, in which chromosomal rearrangements bring the TCL1 gene in close proximity to the T-cell antigen receptor (TCR)-alpha (MIM 186880) or TCR-beta (MIM 186930) regulatory elements (summarized by Virgilio et al., 1998 (PubMed 9520462)). In normal T cells TCL1 is expressed in CD4-/CD8- cells, but not in cells at later stages of differentiation. TCL1 functions as a coactivator of the cell survival kinase AKT (MIM 164730) (Laine et al., 2000 (PubMed 10983986)).(supplied by OMIM, Jul 2010)
Gene ID
8115
Gene Name (Vector)
T-cell leukemia/lymphoma 1A
Gene Symbol
TCL1A
HGNC ID
HGNC:11648
ORF Size (aa)
345
RefSeq ID
NM_021966
RefSeq Synonyms
NM_021966, NM_001098725, BC014024, BC005831, BC003574,
Species
human
UniGene ID
Hs.2484

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.