human TCL1A shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human TCL1A.
shAAV-225227
AAV-h-TCL1A-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human TCL1A (T-cell leukemia/lymphoma 1A). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
TCL1
Description (Vector)
Overexpression of the TCL1 gene in humans has been implicated in the development of mature T cell leukemia, in which chromosomal rearrangements bring the TCL1 gene in close proximity to the T-cell antigen receptor (TCR)-alpha (MIM 186880) or TCR-beta (MIM 186930) regulatory elements (summarized by Virgilio et al., 1998 (PubMed 9520462)). In normal T cells TCL1 is expressed in CD4-/CD8- cells, but not in cells at later stages of differentiation. TCL1 functions as a coactivator of the cell survival kinase AKT (MIM 164730) (Laine et al., 2000 (PubMed 10983986)).(supplied by OMIM, Jul 2010)
Gene ID
8115
Gene Name (Vector)
T-cell leukemia/lymphoma 1A
Gene Symbol
TCL1A
HGNC ID
HGNC:11648
ORF Size (aa)
345
RefSeq ID
NM_021966
RefSeq Synonyms
NM_021966, NM_001098725, BC014024, BC005831, BC003574,
Species
human
UniGene ID
Hs.2484
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.