human TCF7 Over-expression AAV

Name 
AAV-h-TCF7
Cat No 
AAV-225218
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human TCF7.

AAV-225218
AAV-h-TCF7

Ready-to-use AAV expressing Human TCF7 (transcription factor 7 (T-cell specific, HMG-box)). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
T-cell factor 1; T-cell-factor-7; T-cell-specific transcription factor 1; TCF-1; TCF-7; transcription factor 7; transcription factor 7 (T-cell specific, HMG-box)
Description (eCommerce)
TCF1/TCF7 is a member of the T-cell factor/lymphoid enhancer-binding factor family of high mobility group (HMG) box transcriptional activators. TCF1/TCF7 is expressed predominantly in T-cells and plays a critical role in natural killer cell and innate lymphoid cell development by forming a complex with beta-catenin and activating transcription through a Wnt/beta-catenin signaling pathway. [taken from NCBI Entrez Gene (Gene ID: 6932)].
Description (Vector)
TCF7 is a transcriptional activator that plays an important role in lymphocyte differentiation. This gene is expressed predominantly in T-cells. The encoded protein can bind an enhancer element and activate the CD3E gene, and it also may repress the CTNNB1 and TCF7L2 genes through a feedback mechanism. Several transcript variants encoding different isoforms have been found for this gene.
Gene ID
6932
Gene Name (eCommerce)
transcription factor 7
Gene Name (Vector)
transcription factor 7 (T-cell specific, HMG-box)
Gene Symbol
TCF7
HGNC ID
HGNC:11639
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1155
Protein Name (eCommerce)
Transcription factor 7
RefSeq ID
NM_003202
RefSeq Synonyms
NM_213648, NM_201634, NM_201632, NM_003202, NM_001346450, NM_001346425, NM_001134851, BC072023, BC048769,
Research Areas
Apoptosis,Brain Development,Cancer,Cardiology,Cardiomyopathy,Cardiovascular,Colorectal Cancer,Hippo Signaling,Immunology,Interleukin Signaling,Leukemia,Neurobiology,Neurodevelopment,Neurogenesis,Prostate Cancer,Signal Transduction,Transcription Factor/Regulator,Wnt Signaling
Research Areas (Faceted)
cancer,cardiovascular,cell_biology,developmental_biology,immunology,neurobiology,signal_transduction,transcription_translation
Species
human
Target Sentence
TCF1/TCF7 is a member of the T-cell factor/lymphoid enhancer-binding factor family of high mobility group (HMG) box transcriptional activators. TCF1/TCF7 is expressed predominantly in T-cells and plays a critical role in natural killer cell and innate lymphoid cell development by forming a complex with beta-catenin and activating transcription through a Wnt/beta-catenin signaling pathway. [taken from NCBI Entrez Gene (Gene ID: 6932)].
UniGene ID
Hs.573153
UniProt ID (eCommerce)
P36402

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.