human TCF7 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human TCF7.
shAAV-225218
AAV-h-TCF7-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human TCF7 (transcription factor 7 (T-cell specific, HMG-box)). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
T-cell factor 1; T-cell-factor-7; T-cell-specific transcription factor 1; TCF-1; TCF-7; transcription factor 7; transcription factor 7 (T-cell specific, HMG-box)
Description (eCommerce)
TCF1/TCF7 is a member of the T-cell factor/lymphoid enhancer-binding factor family of high mobility group (HMG) box transcriptional activators. TCF1/TCF7 is expressed predominantly in T-cells and plays a critical role in natural killer cell and innate lymphoid cell development by forming a complex with beta-catenin and activating transcription through a Wnt/beta-catenin signaling pathway. [taken from NCBI Entrez Gene (Gene ID: 6932)].
Description (Vector)
TCF7 is a transcriptional activator that plays an important role in lymphocyte differentiation. This gene is expressed predominantly in T-cells. The encoded protein can bind an enhancer element and activate the CD3E gene, and it also may repress the CTNNB1 and TCF7L2 genes through a feedback mechanism. Several transcript variants encoding different isoforms have been found for this gene.
Gene ID
6932
Gene Name (eCommerce)
transcription factor 7
Gene Name (Vector)
transcription factor 7 (T-cell specific, HMG-box)
Gene Symbol
TCF7
HGNC ID
HGNC:11639
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1155
Protein Name (eCommerce)
Transcription factor 7
RefSeq ID
NM_003202
RefSeq Synonyms
NM_213648, NM_201634, NM_201632, NM_003202, NM_001346450, NM_001346425, NM_001134851, BC072023, BC048769,
Research Areas
Apoptosis,Brain Development,Cancer,Cardiology,Cardiomyopathy,Cardiovascular,Colorectal Cancer,Hippo Signaling,Immunology,Interleukin Signaling,Leukemia,Neurobiology,Neurodevelopment,Neurogenesis,Prostate Cancer,Signal Transduction,Transcription Factor/Regulator,Wnt Signaling
Research Areas (Faceted)
cancer,cardiovascular,cell_biology,developmental_biology,immunology,neurobiology,signal_transduction,transcription_translation
Species
human
Target Sentence
TCF1/TCF7 is a member of the T-cell factor/lymphoid enhancer-binding factor family of high mobility group (HMG) box transcriptional activators. TCF1/TCF7 is expressed predominantly in T-cells and plays a critical role in natural killer cell and innate lymphoid cell development by forming a complex with beta-catenin and activating transcription through a Wnt/beta-catenin signaling pathway. [taken from NCBI Entrez Gene (Gene ID: 6932)].
UniGene ID
Hs.573153
UniProt ID (eCommerce)
P36402
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.