human STRAP Over-expression AAV

Name 
AAV-h-STRAP
Cat No 
AAV-224636
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human STRAP.

AAV-224636
AAV-h-STRAP

Ready-to-use AAV expressing Human STRAP (serine/threonine kinase receptor associated protein). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
MAP activator with WD repeats; MAWD; PT-WD; serine-threonine kinase receptor-associated protein; unr-interacting protein; UNRIP; WD-40 repeat protein PT-WD
Description (eCommerce)
The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Serine-threonine kinase receptor-associated protein (STRAP) plays a role in the cellular distribution of the SMN complex. It negatively regulates TGF-beta signaling but positively regulates the PDPK1 kinase activity by enhancing its autophosphorylation and by significantly reducing the association of PDPK1 with 14-3-3 protein [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q9Y3F4].
Gene ID
11171
Gene Name (eCommerce)
serine/threonine kinase receptor associated protein
Gene Name (Vector)
serine/threonine kinase receptor associated protein
Gene Symbol
STRAP
HGNC ID
HGNC:30796
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1053
ORF Size (bp)
1053 bp
Protein Name (eCommerce)
Serine-threonine kinase receptor-associated protein
RefSeq ID
NM_007178
RefSeq Synonyms
NM_007178, BC062306, BC000162,
Research Areas
Gene Expression,Mitochondrion,mRNA Processing,mRNA Splicing,RNA Processing,RNA Transport,Signal Transduction,TGF-beta Signaling
Research Areas (Faceted)
cell_biology,genetics,immunology,signal_transduction,transcription_translation
Species
human
Target Sentence
The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Serine-threonine kinase receptor-associated protein (STRAP) plays a role in the cellular distribution of the SMN complex. It negatively regulates TGF-beta signaling but positively regulates the PDPK1 kinase activity by enhancing its autophosphorylation and by significantly reducing the association of PDPK1 with 14-3-3 protein [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q9Y3F4].
UniGene ID
Hs.504895
UniProt ID (eCommerce)
Q9Y3F4

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.