human SIRT3 Over-expression AAV

Name 
AAV-h-SIRT3
Cat No 
AAV-223017
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human SIRT3.

AAV-223017
AAV-h-SIRT3

Ready-to-use AAV expressing Human SIRT3 (sirtuin 3). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
SIR2L3
Description (Vector)
SIRT3 encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Two alternatively spliced transcript variants that encode different proteins have been described for this gene.
Gene ID
23410
Gene Name (Vector)
sirtuin 3
Gene Symbol
SIRT3
HGNC ID
HGNC:14931
ORF Size (aa)
1200
ORF Size (bp)
1200 bp
RefSeq ID
NM_012239
RefSeq Synonyms
NM_012239, NM_001017524, BC001042,
Species
human
UniGene ID
Hs.716456

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.