human SGCG Over-expression AAV

Name 
AAV-h-SGCG
Cat No 
AAV-222844
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human SGCG.

AAV-222844
AAV-h-SGCG

Ready-to-use AAV expressing Human SGCG (sarcoglycan gamma). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
35DAG; A4; DAGA4; DMDA; DMDA1; gamma-SG; LGMD2C; MAM; SCARMD2; SCG3
Description (Vector)
SGCG encodes gamma-sarcoglycan, one of several sarcolemmal transmembrane glycoproteins that interact with dystrophin. The dystrophin-glycoprotein complex (DGC) spans the sarcolemma and is comprised of dystrophin, syntrophin, alpha- and beta-dystroglycans and sarcoglycans. The DGC provides a structural link between the subsarcolemmal cytoskeleton and the extracellular matrix of muscle cells. Defects in the encoded protein can lead to early onset autosomal recessive muscular dystrophy, in particular limb-girdle muscular dystrophy, type 2C (LGMD2C).
Gene ID
6445
Gene Name (Vector)
sarcoglycan gamma
Gene Symbol
SGCG
HGNC ID
HGNC:10809
ORF Size (aa)
876
RefSeq ID
NM_000231
RefSeq Synonyms
NM_000231, BC109321, BC074778, BC074777,
Species
human
UniGene ID
Hs.37167

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.