mouse TFRC shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Mouse Tfrc.
shADV-274094
Ad-m-TFRC-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Mouse Tfrc (transferrin receptor). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
2610028K12Rik; CD71; E430033M20Rik; Mtvr1; p90; TFR; TFR1; TR; Trfr
Description (Vector)
Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). A second ligand, the heditary hemochromatosis protein HFE, competes for binding with transferrin for an overlapping C-terminal binding site.
Gene ID
22042
Gene Name (Vector)
transferrin receptor
Gene Symbol
Tfrc
ORF Size (aa)
2292
ORF Size (bp)
2292 bp
RefSeq ID
NM_011638
RefSeq Synonyms
NM_011638, BC054522,
Species
mouse
UniGene ID
Mm.28683
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.