mouse NOX4 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Mouse Nox4.
shADV-265956
Ad-m-NOX4-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Mouse Nox4 (NADPH oxidase 4). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
AI648021
Description (Vector)
Constitutive NADPH oxidase which generates superoxide intracellularly upon formation of a complex with CYBA/p22phox. Regulates signaling cascades probably through phosphatases inhibition. May function as an oxygen sensor regulating the KCNK3/TASK-1 potassium channel and HIF1A activity. May regulate insulin signaling cascade. May play a role in apoptosis, bone resorption and lipolysaccharide-mediated activation of NFKB. May produce superoxide in the nucleus and play a role in regulating gene expression upon cell stimulation. Isoform 3 is not functional. Isoform 4 displays an increased activity. Isoform 5 and isoform 6 display reduced activity.
Gene ID
50490
Gene Name (Vector)
NADPH oxidase 4
Gene Symbol
Nox4
ORF Size (aa)
1737
ORF Size (bp)
1737 bp
RefSeq ID
NM_015760
RefSeq Synonyms
NM_015760, NM_001285835, NM_001285833, BC165954, BC138918,
Species
mouse
UniGene ID
Mm.31748
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.