mouse ITGB3BP shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Mouse Itgb3bp.
shADV-262455
Ad-m-ITGB3BP-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Mouse Itgb3bp (integrin beta 3 binding protein (beta3-endonexin)). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
4930471O16Rik; AU022583
Description (Vector)
Transcription coregulator that can have both coactivator and corepressor functions. Isoform 1, but not other isoforms, is involved in the coactivation of nuclear receptors for retinoid X (RXRs) and thyroid hormone (TRs) in a ligand-dependent fashion. In contrast, it does not coactivate nuclear receptors for retinoic acid, vitamin D, progesterone receptor, nor glucocorticoid. Acts as a coactivator for estrogen receptor alpha. Acts as a transcriptional corepressor via its interaction with the NFKB1 NF-kappa-B subunit, possibly by interfering with the transactivation domain of NFKB1. Induces apoptosis in breast cancer cells, but not in other cancer cells, via a caspase-2 mediated pathway that involves mitochondrial membrane permeabilization but does not require other caspases. May also act as an inhibitor of cyclin A-associated kinase. Also acts a component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex.
Gene ID
67733
Gene Name (Vector)
integrin beta 3 binding protein (beta3-endonexin)
Gene Symbol
Itgb3bp
ORF Size (aa)
531
RefSeq ID
NM_026348
RefSeq Synonyms
NM_026348, BC049557,
Species
mouse
UniGene ID
Mm.257094
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.