human ITGB3BP shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human ITGB3BP.
shADV-212510
Ad-h-ITGB3BP-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human ITGB3BP (integrin subunit beta 3 binding protein). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
CENP-R; CENPR; HSU37139; NRIF3; TAP20
Description (Vector)
ITGB3BP encodes a transcriptional coregulator that binds to and enhances the activity of members of the nuclear receptor families, thyroid hormone receptors and retinoid X receptors. This protein also acts as a corepressor of NF-kappaB-dependent signaling. This protein induces apoptosis in breast cancer cells through a caspase 2-mediated signaling pathway. This protein is also a component of the centromere-specific histone H3 variant nucleosome associated complex (CENP-NAC) and may be involved in mitotic progression by recruiting the histone H3 variant CENP-A to the centromere. Alternate splicing results in multiple transcript variants.
Gene ID
23421
Gene Name (Vector)
integrin subunit beta 3 binding protein
Gene Symbol
ITGB3BP
HGNC ID
HGNC:6157
ORF Size (aa)
534
RefSeq ID
NM_014288
RefSeq Synonyms
NM_014288, NM_001347148, NM_001347147, NM_001347145, NM_001206739, BC014385, BC009929,
Species
human
UniGene ID
Hs.166539
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.