mouse IPO7 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Mouse Ipo7.
shADV-262323
Ad-m-IPO7-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Mouse Ipo7 (importin 7). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
A330055O14Rik; C330016G14; Imp7; Ranbp7
Description (Vector)
Functions in nuclear protein import, either by acting as autonomous nuclear transport receptor or as an adapter-like protein in association with the importin-beta subunit KPNB1. Acting autonomously, is thought to serve itself as receptor for nuclear localization signals (NLS) and to promote translocation of import substrates through the nuclear pore complex (NPC) by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Mediates autonomously the nuclear import of ribosomal proteins RPL23A, RPS7 and RPL5. Binds to a beta-like import receptor binding (BIB) domain of RPL23A. In association with KPNB1 mediates the nuclear import of H1 histone and the Ran-binding site of IPO7 is not required but synergizes with that of KPNB1 in importin/substrate complex dissociation. In vitro, mediates nuclear import of H2A, H2B, H3 and H4 histones. In vitro, mediates the nuclear import of HIV-1 reverse transcription complex (RTC) integrase. In case of HIV-1 infection, binds and mediates the nuclear import of HIV-1 Rev.
Gene ID
233726
Gene Name (Vector)
importin 7
Gene Symbol
Ipo7
ORF Size (aa)
3114
ORF Size (bp)
3114 bp
RefSeq ID
NM_181517
RefSeq Synonyms
NM_181517, BC141510,
Species
mouse
UniGene ID
Mm.476899
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.