human SIPA1 Adenovirus
This is an Adenovirus expressing Human SIPA1.
ADV-223008
Ad-h-SIPA1
Ready-to-use Adenovirus expressing Human SIPA1 (signal-induced proliferation-associated 1). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
GTPase-activating protein Spa-1; p130 SPA-1; signal-induced proliferation-associated gene 1; signal-induced proliferation-associated protein 1; sipa-1; SPA1
Description (eCommerce)
The regulation of GTPase activity is achieved via activators called GEFs (guanine-nucleotide exchange factors) and inactivators called GAPs (GTPase-activating proteins). Signal-induced proliferation-associated protein 1 (SIPA1) is a GTPase activating protein (GAP) for the Rap1 and Rap2 small GTPases. Spa-1 has been found to play an important role in hematopoietic cell development and the invasion and metastasis of human cancers.
Description (Vector)
The product of this gene is a mitogen induced GTPase activating protein (GAP). It exhibits a specific GAP activity for Ras-related regulatory proteins Rap1 and Rap2, but not for Ran or other small GTPases. This protein may also hamper mitogen-induced cell cycle progression when abnormally or prematurely expressed. It is localized to the perinuclear region. Two alternatively spliced variants encoding the same isoform have been characterized to date.
Gene ID
6494
Gene Name (eCommerce)
signal-induced proliferation-associated 1
Gene Name (Vector)
signal-induced proliferation-associated 1
Gene Symbol
SIPA1
HGNC ID
HGNC:10885
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
3129
ORF Size (bp)
3129 bp
Protein Name (eCommerce)
Signal-induced proliferation-associated protein 1
RefSeq ID
NM_006747
RefSeq Synonyms
NM_153253, NM_006747, BC110353, BC010492,
Research Areas
Cell Cycle,Cytoskeleton,Immunology,MAPK Signaling,PDGF Signaling,Signal Transduction
Research Areas (Faceted)
cell_biology,cell_cycle,genetics,immunology,signal_transduction
Species
human
Target Sentence
The regulation of GTPase activity is achieved via activators called GEFs (guanine-nucleotide exchange factors) and inactivators called GAPs (GTPase-activating proteins). Signal-induced proliferation-associated protein 1 (SIPA1) is a GTPase activating protein (GAP) for the Rap1 and Rap2 small GTPases. Spa-1 has been found to play an important role in hematopoietic cell development and the invasion and metastasis of human cancers.
UniGene ID
Hs.530477
UniProt ID (eCommerce)
Q96FS4
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.