human ZYX shRNA silencing Adenovirus

Name
Ad-h-ZYX-shRNA

Cat No
shADV-229020

Availability
4-5 weeks

This is an Adenovirus expressing shRNA for silencing of Human ZYX.

shADV-229020

Ad-h-ZYX-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human ZYX (zyxin). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

shRNA Validated

Yes

Storage Buffer

DMEM, 2% BSA, 2.5% Glycerol

Viral Backbone

Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names

ESP-2; HED-2

Description (Vector)

Focal adhesions are actin-rich structures that enable cells to adhere to the extracellular matrix and at which protein complexes involved in signal transduction assemble. Zyxin is a zinc-binding phosphoprotein that concentrates at focal adhesions and along the actin cytoskeleton. Zyxin has an N-terminal proline-rich domain and three LIM domains in its C-terminal half. The proline-rich domain may interact with SH3 domains of proteins involved in signal transduction pathways while the LIM domains are likely involved in protein-protein binding. Zyxin may function as a messenger in the signal transduction pathway that mediates adhesion-stimulated changes in gene expression and may modulate the cytoskeletal organization of actin bundles. Alternative splicing results in multiple transcript variants that encode the same isoform.

Gene ID

7791

Gene Name (Vector)

zyxin

Gene Symbol

ZYX

HGNC ID

HGNC:13200

ORF Size (aa)

1719

ORF Size (bp)

1719 bp

RefSeq ID

NM_003461

RefSeq Synonyms

NM_003461, NM_001010972, BC010031, BC009360, BC008743,

Species

human

UniGene ID

Hs.490415

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.