human ZYX shRNA silencing AAV
Category: AAV > shRNA-Silencing
Cat. No: shAAV-229020
Availability:
4-5 weeks
Name:
AAV-h-ZYX-shRNA
This is an AAV expressing shRNA for silencing of Human ZYX.
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Product Info
- Knockdown
- >90% knockdown of mRNA in cultured cells
Viral Details
- Viral Backbone
- Recombinant AAV
- AAV-ITR
- AAV2
- AAV Serotype
- Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
- Promoter
- U6
- Reporter
- eGFP (default), optional CFP, YFP, RFP, mCherry
- Storage Buffer
- PBS/5% Glycerol
Gene Details
- Species
- Human
- Gene Symbol
- ZYX
- Gene Name
- zyxin
- Gene ID
- 7791
- Gene Synonyms
- ESP-2; HED-2
- ORF Size
- 1719 bp
- RefSeq#
- NM_003461
- Gene Description
- Focal adhesions are actin-rich structures that enable cells to adhere to the extracellular matrix and at which protein complexes involved in signal transduction assemble. Zyxin is a zinc-binding phosphoprotein that concentrates at focal adhesions and along the actin cytoskeleton. Zyxin has an N-terminal proline-rich domain and three LIM domains in its C-terminal half. The proline-rich domain may interact with SH3 domains of proteins involved in signal transduction pathways while the LIM domains are likely involved in protein-protein binding. Zyxin may function as a messenger in the signal transduction pathway that mediates adhesion-stimulated changes in gene expression and may modulate the cytoskeletal organization of actin bundles. Alternative splicing results in multiple transcript variants that encode the same isoform.
- UniGene ID
- Hs.490415
- HGNC ID
- HGNC:13200
Related Products
Product | Cat No. |
---|---|
AAV-h-ZYX | AAV-229020 |
AAV-m-ZYX | AAV-277172 |
Ad-h-ZYX | ADV-229020 |
Ad-m-ZYX | ADV-277172 |
AAV-m-ZYX-shRNA | shAAV-277172 |
Ad-h-ZYX-shRNA | shADV-229020 |
Ad-m-ZYX-shRNA | shADV-277172 |
Control Products
Product | Cat No. |
---|---|
AAV1-GFP-U6-shRNA | 7040 |
AAV2-GFP-U6-shRNA | 7041 |
AAV5-GFP-U6-shRNA | 7042 |
AAV6-GFP-U6-shRNA | 7043 |
AAV9-GFP-U6-shRNA | 7045 |
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