human RIF1 shRNA silencing Adenovirus

Name 
Ad-h-RIF1-shRNA
Cat No 
shADV-221227
Availability
7-8 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human RIF1.

shADV-221227
Ad-h-RIF1-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human RIF1 (replication timing regulatory factor 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Validated
No
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
RAP1 interacting factor homolog; rap1-interacting factor 1 homolog; telomere-associated protein RIF1
Description (eCommerce)
RAP1 interacting factor (RIF1) localizes to dysfunctional telomeres and functions in the S-phase checkpoint. In response to double-stranded breaks (DSBs), RIF1 functions in the ATM and ATR mediated response to DNA damage. RIF1 foci formation in response to DNA damage is completely dependent on ATM.
Description (Vector)
RIF1 encodes a protein that shares homology with the yeast teleomere binding protein, Rap1 interacting factor 1. This protein localizes to aberrant telomeres may be involved in DNA repair. Alternate splicing results in multiple transcript variants.
Gene ID
55183
Gene Name (eCommerce)
replication timing regulatory factor 1
Gene Name (Vector)
replication timing regulatory factor 1
Gene Symbol
RIF1
HGNC ID
HGNC:23207
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
7419
ORF Size (bp)
7419 bp
Protein Name (eCommerce)
Telomere-associated protein RIF1
RefSeq ID
NM_018151
RefSeq Synonyms
NM_018151, NM_001177665, NM_001177664, NM_001177663, BC172393,
Research Areas
Cell Cycle,Cytoskeleton,DNA Damage/Repair,Telomeric Maintenance
Research Areas (Faceted)
cell_biology,cell_cycle,genetics,transcription_translation
Species
human
Target Sentence
RAP1 interacting factor (RIF1) localizes to dysfunctional telomeres and functions in the S-phase checkpoint. In response to double-stranded breaks (DSBs), RIF1 functions in the ATM and ATR mediated response to DNA damage. RIF1 foci formation in response to DNA damage is completely dependent on ATM.
UniGene ID
Hs.655671
UniProt ID (eCommerce)
Q5UIP0

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.