human PDLIM5 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human PDLIM5.
shADV-218547
Ad-h-PDLIM5-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human PDLIM5 (PDZ and LIM domain 5). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
ENH; ENH1; enigma homolog; enigma-like LIM domain protein; enigma-like PDZ and LIM domains protein; L9; LIM; PDZ and LIM domain protein 5
Description (eCommerce)
The PDZ and LIM domain 5 protein (PDLIM5) bears a PDZ (post-synaptic density-95/discs large/zone occludens-1) domain and three LIM (Lin-11 Isl-1 mec03) zinc-binding domains. PDLIM5 may function as an adaptor protein that mediates protein-protein interactions and interactions with the actin cytoskeleton. PDLIM5 has been implicated in the development of schizophrenia and bipolar disorder.
Description (Vector)
PDLIM5 encodes a member of a family of proteins that possess a 100-amino acid PDZ domain at the N terminus and one to three LIM domains at the C-terminus. This family member functions as a scaffold protein that tethers protein kinases to the Z-disk in striated muscles. It is thought to function in cardiomyocyte expansion and in restraining postsynaptic growth of excitatory synapses. Alternative splicing of this gene results in multiple transcript variants.
Gene ID
10611
Gene Name (eCommerce)
PDZ and LIM domain 5
Gene Name (Vector)
PDZ and LIM domain 5
Gene Symbol
PDLIM5
HGNC ID
HGNC:17468
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1791
ORF Size (bp)
1791 bp
Protein Name (eCommerce)
PDZ and LIM domain protein 5
RefSeq ID
NM_006457
RefSeq Synonyms
NM_006457, NM_001256429, NM_001256428, NM_001256427, NM_001256426, NM_001256425, NM_001011516, NM_001011515, NM_001011513, BC017902, BC008741,
Research Areas
Cytoskeleton,Immunology,Neurobiology,Synapse
Research Areas (Faceted)
cell_biology,immunology,neurobiology
Species
human
Target Sentence
The PDZ and LIM domain 5 protein (PDLIM5) bears a PDZ (post-synaptic density-95/discs large/zone occludens-1) domain and three LIM (Lin-11 Isl-1 mec03) zinc-binding domains. PDLIM5 may function as an adaptor protein that mediates protein-protein interactions and interactions with the actin cytoskeleton. PDLIM5 has been implicated in the development of schizophrenia and bipolar disorder.
UniGene ID
Hs.480311
UniProt ID (eCommerce)
Q96HC4
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.