human PFDN2 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human PFDN2.
shAAV-218660
AAV-h-PFDN2-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human PFDN2 (prefoldin subunit 2). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
PFD2; prefoldin 2; prefoldin subunit 2
Description (eCommerce)
PFDN2/Prefoldin 2 binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. It binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q9UHV9].
Description (Vector)
PFDN2 encodes a member of the prefoldin beta subunit family. The encoded protein is one of six subunits of prefoldin, a molecular chaperone complex that binds and stabilizes newly synthesized polypeptides, thereby allowing them to fold correctly. The complex, consisting of two alpha and four beta subunits, forms a double beta barrel assembly with six protruding coiled-coils.
Gene ID
5202
Gene Name (eCommerce)
prefoldin subunit 2
Gene Name (Vector)
prefoldin subunit 2
Gene Symbol
PFDN2
HGNC ID
HGNC:8867
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
465
Protein Name (eCommerce)
Prefoldin subunit 2
RefSeq ID
NM_012394
RefSeq Synonyms
NM_012394, BC047042, BC012464,
Research Areas
Metabolism/Metabolic Process,Mitochondrion,Protein Folding,Signal Transduction,TNF Signaling,Translational Control
Research Areas (Faceted)
cell_biology,metabolism,signal_transduction,transcription_translation
Species
human
Target Sentence
PFDN2/Prefoldin 2 binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. It binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q9UHV9].
UniGene ID
Hs.492516
UniProt ID (eCommerce)
Q9UHV9
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.