human IMPDH2 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human IMPDH2.
shADV-212246
Ad-h-IMPDH2-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human IMPDH2 (inosine monophosphate dehydrogenase 2). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
IMPD2; IMPDH-II
Description (Vector)
IMPDH2 encodes the rate-limiting enzyme in the de novo guanine nucleotide biosynthesis. It is thus involved in maintaining cellular guanine deoxy- and ribonucleotide pools needed for DNA and RNA synthesis. The encoded protein catalyzes the NAD-dependent oxidation of inosine-5'-monophosphate into xanthine-5'-monophosphate, which is then converted into guanosine-5'-monophosphate. IMPDH2 is up-regulated in some neoplasms, suggesting it may play a role in malignant transformation.
Gene ID
3615
Gene Name (Vector)
inosine monophosphate dehydrogenase 2
Gene Symbol
IMPDH2
HGNC ID
HGNC:6053
ORF Size (aa)
1545
ORF Size (bp)
1545 bp
RefSeq ID
NM_000884
RefSeq Synonyms
NM_000884, BC015567, BC012840, BC006124,
Species
human
UniGene ID
Hs.654400
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.